“Anti-microbial Study and Synthesis of Schiff bases of 3-actyl 4-hydroxy Quinolin-2-one”

Quinoline based new Schiff bases were synthesized from 3-Actyl 4-Hydroxy Quinolin-2-(1H)-one and screened their antibacterial antifungal activity. The 4-hydroxy-3-(1-((4-picolin-2-yl)imino)ethyl)quinolin-2-(1H)-one(L1),4-hydroxy-3-(1-((5-picolin-2-yl)imino)ethyl)quinolin-2(1H)-one(L2),4-hydroxy-3-(1-((6-picolin-2-yl)-imino)ethyl)quinolin-2(1H)-one(L3) 4-hydroxy-3-(1-((3-nitro-4-picolin-2-yl)imino)ethyl)quinolin-2-(1H)-one (L4) preparedfrom 3-Acetyl Quinolin-2-One with 2-amino picolines. structures of confirmed by Infrared, mass, proton-NMR 13CNMR spectral analysis. In vitro studies these carried out for activity Agar contact method the poison plate method. bacterial species used B. subtilis, E. coli, S. typhi, aureus. Fungal F. moneliforme, A.niger, A. flavus, P. chrysogenum.